PS315, a derivative of PS48 (HY-15967), is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKCzeta (IC50=10 µM) and PKCeta (IC50=30 µM). PS315 has anti-cancer activity[1].
Molecular Weight:
362.85
CAS Number:
[1221964-50-6]
Formula:
C23H19ClO2
Target:
PKC
Application Notes:
MCE Product type: Reference compound
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