NHI-2 is a lactate dehydrogenase A (LDHA) inhibitor with an IC50 of 14.7 µM. NHI-2 shows selective for LDHA over LDHB (IC50 = 55.8 µM). NHI-2 is an efficient anti-glycolytic agent. NHI-2 enhances apoptosis, induces cell cycle arrest at S and G2 phases. NHI-2 has a broad spectrum anti-proliferative activity in cancer cells. NHI-2 affects extracellular acidification rate and ATP production. NHI-2 suppresses tumor growth in murine B78 melanoma tumor model[1][2].
Molecular Weight:
335.28
Purity:
99.10
CAS Number:
[1269802-97-2]
Formula:
C17H12F3NO3
Target:
Apoptosis,Lactate Dehydrogenase
Application Notes:
MCE Product type: Reference compound
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