JNJ525 is a TNFalpha inhibitor with IC50 values of 1.2 µM and 1.1 µM against TNFR1 and TNFR2, respectively. JNJ525 forms ordered aggregates and induces quaternary structural transition of TNFalpha, thereby blocking the protein-protein interaction between TNFalpha and its receptors. The inhibitory activity of JNJ525 is completely lost in the presence of 0.1% Triton X-100[1].
Molecular Weight:
514.62
Purity:
99.93
CAS Number:
[2092913-64-7]
Formula:
C31H30N8
Target:
TNF Receptor
Application Notes:
MCE Product type: Reference compound
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