12(S)-HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12(S)-HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells[1][2].
Molecular Weight:
320.47
Purity:
99.10
CAS Number:
[54397-83-0]
Formula:
C20H32O3
Target:
DNA/RNA Synthesis,ERK,p38 MAPK
Application Notes:
MCE Product type: Reference compound
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