SBI-477 is a chemical probe that stimulates insulin signaling by deactivating the transcription factor MondoA. SBI-477 can lead to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4). SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes[1].
Molecular Weight:
483.54
Purity:
98
CAS Number:
[781628-99-7]
Formula:
C24H25N3O6S
Target:
Arrestin,Fluorescent Dye,Insulin Receptor,LXR
Application Notes:
MCE Product type: Reference compound
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