PF-5006739 is a potent and selective inhibitor of CK1delta/epsilon with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1delta/epsilon and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner[1]. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity[2].
Molecular Weight:
419.45
Purity:
99.94
CAS Number:
[1293395-67-1]
Formula:
C22H22FN7O
Target:
Casein Kinase
Application Notes:
MCE Product type: Reference compound
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