SMK-17 is a selective, non-ATP-competitive MEK1/MEK2 inhibitor with IC50s of 62 nM and 56 nM, respectively. SMK-17 binds to the allosteric pocket of MEK1/2. SMK-17 induces apoptosis in tumor cell lines harboring beta-catenin mutations[1].
Molecular Weight:
584.85
CAS Number:
[765958-29-0]
Formula:
C20H24ClF2IN4O2S
Target:
Apoptosis,MEK
Application Notes:
MCE Product type: Reference compound1
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