GK-136901 is an orally active, dual Nox1/Nox4 NADPH oxidase inhibitor with a Ki of 160 nM for Nox1 and 165 nM for Nox4. GK-136901 potently blocks high glucose-induced intracellular reactive oxygen species production, p38-MAPK phosphorylation, and upregulation of TGF-beta1/2 and fibronectin (fibronectin) in renal cells. GK-136901 also inhibits the proliferation of mouse pulmonary vascular cells under hypoxic conditions. GK-136901 is applicable to the research on the pathogenesis of type 2 diabetic nephropathy, high glucose-related renal lesions and pulmonary hypertension[1][2][3][4].
Molecular Weight:
346.38
CAS Number:
[1062624-71-8]
Formula:
C20H18N4O2
Target:
NADPH Oxidase,p38 MAPK,Reactive Oxygen Species (ROS),TGF-beta Receptor
Application Notes:
MCE Product type: Reference compound
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