Duocarmycin A, CAS [[118292-34-5]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-12455
Supplier Catalog Number:
HY-12455
Alternative Catalog Number:
MCE-HY-12455-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Duocarmycin A is an antitumor antibiotic and DNA alkylating agent with broad-spectrum antibacterial activity, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). Duocarmycin A selectively binds to the AT-rich minor groove of DNA, forms covalent adducts by alkylating the adenine N3 residue, thereby disrupting DNA structure and inhibiting its replication and transcription. Duocarmycin A induces cell apoptosis (apoptosis), sub-G1 phase accumulation and chromatin condensation, reduces the levels of pro-caspase-3/9, and induces p53-independent p21 expression. Duocarmycin A is widely used in the research of various malignancies, including leukemia, sarcoma, glioblastoma, as well as multiple solid tumor models such as lung cancer, breast cancer, and colorectal cancer[1][2][3].
