CAD031 is an orally active AMPK/ACC1 signaling pathway activator and a derivative of the Alzheimers disease (AD) targeted agent J147 (HY-13779) (more active than J147 in human neural stem cell assays). CAD031 can cross the blood-brain barrier, activate AMPK and inhibit ACC1, thereby increasing ac-CoA levels, improving mitochondrial function and reducing free fatty acid synthesis. CAD031 has neuroprotective, neurogenesis-promoting and memory-improving activities and can be used in the study of Alzheimers disease and aging-related neurodegenerative diseases. CAD031 effectively enhances the memory of mice, improves dendritic structure, and stimulates cell division in the germinal zone of the brain of elderly mice[1][2][3].
Molecular Weight:
404.31
Purity:
99.39
CAS Number:
[2071209-49-7]
Formula:
C18H14F6N2O2
Target:
Acetyl-CoA Carboxylase,AMPK
Application Notes:
MCE Product type: Reference compound
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