DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 µM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 µM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.
Molecular Weight:
345.23
CAS Number:
[2222660-40-2]
Formula:
C13H10F3N3O5
Target:
Parasite
Application Notes:
MCE Product type: Reference compound1
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