ER-464195-01 is an orally active calreticulin (CRT) and integrin alpha subunits (ITGAs) binding inhibitor. ER-464195-01 inhibits leukocyte infiltration and subsequent inflammatory cascade reactions by dissociating the binding between CRT and ITGA. ER-464195-01 down-regulates the expression of pro-inflammatory genes (such as TNF-alpha, IL-1beta, IL-6, IL-17f) induced by DSS (HY-116282C), and inhibit the phosphorylation of STAT3 and the production of serum amyloid A (SAA). ER-464195-01 can be used for the study of inflammatory bowel disease (IBD)[1].
Molecular Weight:
379.02
Purity:
99.72
CAS Number:
[859218-37-4]
Formula:
C23H39ClN2
Target:
Interleukin Related,STAT,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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