D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-strand annealing (SSA) and D-loop formation with IC50s of 5 µM and 8 µM, respectively. D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells and inhibits formation of damage-induced RAD52 foci, but does not effect on RAD51 foci induced by Cisplatin[1][2].
Molecular Weight:
428.64
Purity:
99.70
CAS Number:
[688342-78-1]
Formula:
C23H36N6S
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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