Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a Ki of 20 µM (hDMT1). Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC50 of 13.8 µM[1].
Molecular Weight:
204.23
CAS Number:
[65004-42-4]
Formula:
C10H12N4O
Target:
Ferroportin
Application Notes:
MCE Product type: Reference compound
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