DKFZ-251 is a kininogenase-related peptidase KLK6 inhibitor (IC50 = 0.47 µM), and also exhibits certain inhibitory activity against KLK5 and KLK7 (IC50 values are 1.1 nM and 73 nM, respectively). DKFZ-251 transiently acylates the catalytic serine of KLK6 to form a long-lived acyl-enzyme complex that inhibits enzyme function. DKFZ-251 is a phenotypic modulator that alters cell proliferation capacity and regulates epithelial-mesenchymal transition (EMT). DKFZ-251 can be used in research related to head and neck cancer[1].
Molecular Weight:
416.48
CAS Number:
[2222059-70-1]
Formula:
C24H24N4O3
Target:
Kallikrein
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
