KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM. KY-05009 pharmacologically inhibits TGF-beta1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity[1].
Molecular Weight:
352.41
Purity:
99.88
CAS Number:
[1228280-29-2]
Formula:
C18H16N4O2S
Target:
Apoptosis,MAP4K,Wnt
Application Notes:
MCE Product type: Reference compound1
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