NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research[1].
Molecular Weight:
439.57
Purity:
99.69
CAS Number:
[1120332-55-9]
Formula:
C24H29N3O3S
Target:
Interleukin Related,Reactive Oxygen Species (ROS),TNF Receptor,Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound1
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