FiVe1 is a vimentin (VIM) inhibitor. FiVe1 binds to the rod domain of VIM, causing metaphase VIM disassembly and hyperphosphorylation at Ser56, ultimately leading to mitotic catastrophe, multinucleation, and loss of stemness. FiVe1 has anticancer activity against soft tissue sarcomas. FiVe1 increases the sensitivity of ovarian cancer to Cisplatin (HY-17394). FiVe1 can be used for researches of mesenchymal cancers (including breast cancer and soft tissue sarcoma) and ovarian cancers[1][2][3].
Molecular Weight:
359.25
Purity:
99.87
CAS Number:
[932359-76-7]
Formula:
C18H16Cl2N4
Target:
Mitosis,Proteasome
Application Notes:
MCE Product type: Reference compound
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