MMRi6 is a Mdm2-MdmX RING domain inhibitor that can disrupt Mdm2-MdmX RING-RING interaction in vitro. MMRi6 inhibits MdmX-stimulated Mdm2 autoubiquitination and Mdm2-MdmX-mediated p53 polyubiquitination in vitro without affecting NEDD4-1 autoubiquitination. MMRi6 induces p53 stabilization and accumulation and induces PARP cleavage in wt-p53 Emu-myc lymphoma cells. MMRi6 inhibits the growth of wt-p53 and p53-null Emu-myc lymphoma cells with IC50s of approximately 0.5 µM and 3 µM, respectively. MMRi6 can be used for the study of leukemia/lymphoma[1].
Molecular Weight:
396.27
Purity:
99.70
CAS Number:
[709009-15-4]
Formula:
C21H15Cl2N3O
Target:
MDM-2/p53,PARP
Application Notes:
MCE Product type: Reference compound
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