MRLB-223 is a preferential HDAC1 and HDAC2 inhibitor with activity against tumor cells.MRLB-223 induces histone hyperacetylation, intrinsic apoptotic pathway activation, tumor cell apoptosis, Hsp90 hyperacetylation, and caspase-dependent Bcr-Abl degradation.MRLB-223 mediates p53-independent tumor cell death, with activity suppressed by Bcl-2 overexpression, and kills Bcr-Abl-expressing myeloid cells.MRLB-223 exerts effects in mice bearing Eµ-myc lymphomas.MRLB-223 can be used for the research of Eµ-myc lymphoma[1].
Molecular Weight:
449.53
CAS Number:
[937727-03-2]
Formula:
C23H23N5O3S
Target:
Apoptosis,Bcr-Abl,HDAC,HSP
Application Notes:
MCE Product type: Reference compound
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