Rheb inhibitor NR1, CAS [[2216763-38-9]]

Product Overview

• Article Name: Rheb inhibitor NR1, CAS [[2216763-38-9]]
• Biozol Catalog Number: MCE-HY-124798
• Supplier Catalog Number: HY-124798
• Alternative Catalog Number: MCE-HY-124798-10MMX1ML,MCE-HY-124798-5MG,MCE-HY-124798-100MG,MCE-HY-124798-10MG,MCE-HY-124798-50MG,MCE-HY-124798-25MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

Rheb inhibitor NR1 is a Rheb inhibitor with an IC50 of 2.1 µM in the Rheb-IVK assay. Rheb inhibitor NR1 can directly bind Rheb in the switch II domain and selectively inhibit the activation of mechanistic target of rapamycin complex 1 (mTORC1). Rheb inhibitor NR1 inhibits the phosphorylation of mTORC1 driven T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner. Rheb inhibitor NR1 does not influence mTORC2 activity[1]. (Rheb-IVK: Rheb-dependent mTORC1 kinase activity)

Product Properties

• Molecular Weight: 578.30
• Purity: 99.26
• CAS Number: [2216763-38-9]
• Formula: C25H19BrCl2N2O3S
• Target: mTOR

Application Notes

• Application Notes: Reference compound