SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM, Kd=1.5 nM). SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity[1][2].
Molecular Weight:
443.85
Purity:
99.74
CAS Number:
[1523406-39-4]
Formula:
C19H21ClF3N5O2
Target:
Autophagy,PI3K
Application Notes:
Reference compound
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