X-370 is a PI3Kdelta inhibitor (IC50 = 7 nM). X-370 inhibits the survival of leukemia cells, inducing G1 arrest and apoptosis. X-370 blocks PDK1 binding and phosphorylation of MEK1/2, eliminating Akt and Erk1/2 signaling. X-370 can be used in research on B-cell acute lymphoblastic leukemia (B-ALL)[1].
Molecular Weight:
551.59
CAS Number:
[1280725-80-5]
Formula:
C27H31F2N9O2
Target:
Akt,Apoptosis,ERK,MEK,PDK-1,PI3K
Application Notes:
MCE Product type: Reference compound
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