Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC50 is 2.7 µM) and an activator for Nrf2. Nrf2 activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H2O2-induced apoptosis.
Molecular Weight:
265.69
CAS Number:
[75483-04-4]
Formula:
C13H12ClNO3
Target:
Apoptosis,Keap1-Nrf2
Application Notes:
Reference compound
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