MI-223 is a Mcl-1 regulator (Kd = 160 nM). MI-223 binds to the BH1 domain, blocking Mcl-1-stimulated homologous recombination DNA repair, thus sensitizing cancer cells to DNA replication agents. MI-223 can be used in research on cancers such as lung cancer[1].
Molecular Weight:
419.86
CAS Number:
[907166-59-0]
Formula:
C23H18ClN3O3
Target:
Bcl-2 Family
Application Notes:
MCE Product type: Reference compound
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