Bonannione A (6-Geranylnaringenin, Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity[1][2][3].
Molecular Weight:
408.49
Purity:
98
CAS Number:
[97126-57-3]
Formula:
C25H28O5
Target:
Apoptosis,Autophagy,Phosphatase
Application Notes:
MCE Product type: Natural Products
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