QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9µM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint[1][2].
Molecular Weight:
768.56
Purity:
95.00
CAS Number:
[937735-00-7]
Formula:
C39H38Cl4N4O4
Target:
Caspase
Application Notes:
MCE Product type: Reference compound
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