iJak-381 is a JAK1/2 inhibitor with anti-inflammatory activity. iJak-381 blocks IL-13 signaling and also inhibits IL-4 and IL-6 signaling pathways. iJak-381 also reduced p-STAT6 levels and inhibited the influx of inflammatory cells into the lungs of mice. iJak-381 inhibits airway hyperresponsiveness (AHR)[1].
Molecular Weight:
612.03
Purity:
99.86
CAS Number:
[1831144-46-7]
Formula:
C28H28ClF2N9O3
Target:
JAK,STAT
Application Notes:
MCE Product type: Reference compound
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