ITI-214 is a potent, CNS-active, orally bioavailable PDE1 inhibitor (Ki of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. ITI-214 shows efficacy in various animal models of motor and cognitive functions[1][2].
Molecular Weight:
605.56
Purity:
99.58
CAS Number:
[1642303-38-5]
Formula:
C29H29FN7O5P
Target:
Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Reference compound
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