2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495)[1].
Molecular Weight:
440.80
Purity:
99.77
CAS Number:
[2143542-28-1]
Formula:
C19H16ClF3N4O3
Target:
Eukaryotic Initiation Factor (eIF)
Application Notes:
MCE Product type: Reference compound
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