Hck-IN-1 (compound B9), a diphenylpyrazolo compound, is a selective Nef-dependent Hck inhibitor with IC50s of 2.8 µM, >20 µM for Nef:Hck complex and Hck, respectively. Hck-IN-1 is a direct and wide HIV-1 Nef antagonists with an IC50 of 100-300 nM for wild-type HIV-1 replication. Hck-IN-1 binds pocket residue Asn126 and has anti-retroviral activity[1].
Molecular Weight:
402.81
Purity:
98.10
CAS Number:
[1473404-51-1]
Formula:
C16H11ClN6O3S
Target:
HIV,Src
Application Notes:
MCE Product type: Reference compound
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