L-162782 is a high affinity AT1 receptor ligand for rat and human wild-type AT1 with IC50 values of 28.5 and 24.6 nM, respectively. L-162782 acts as a partial agonist (EC50 ~ 30 nM) and insurmountable antagonist (IC50 = 6.5 µM) on wild-type rat AT1 receptors in COS-7 cells. L-162782 reduces Angiotensin II (HY-13948)-induced phosphatidylinositol turnover. L-162782 can be used for hypertension research[1].
Molecular Weight:
576.76
CAS Number:
[169281-92-9]
Formula:
C32H40N4O4S
Target:
Angiotensin Receptor
Application Notes:
MCE Product type: Reference compound
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