AFM-30a is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a binds to PAD2 with an EC50 value of 9.5 µM. AFM-30a also inhibits H3 citrullination with an EC50 value of 0.4 µM. AFM-30a can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis[1].
Molecular Weight:
466.51
Purity:
96
CAS Number:
[2095107-57-4]
Formula:
C24H27FN6O3
Target:
Protein Arginine Deiminase
Application Notes:
MCE Product type: Reference compound
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