Samotolisib (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kalpha, PI3Kbeta, PI3Kdelta, PI3Kgamma, DNA-PK and mTOR, respectively. Samotolisib potently inhibits mTORC1/2 at low nanomolar concentrations[1][2].
Molecular Weight:
406.48
Purity:
99.27
CAS Number:
[1386874-06-1]
Formula:
C23H26N4O3
Target:
Autophagy,DNA-PK,mTOR,PI3K
Application Notes:
MCE Product type: Reference compound
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