A-1293201 is a substrate-independent NAMPT inhibitor with antitumor activity. A-1293201 effectively reduces the total cellular NAD+/NADH (NADt) level, subsequently leading to ATP depletion and cancer cell death. In addition, A-1293201 can effectively overcome the acquired resistance mechanism of the NAMPT Y18 mutant to CHS-828 (HY-10079)[1].
Molecular Weight:
365.43
Purity:
99.82
CAS Number:
[1375557-33-7]
Formula:
C21H23N3O3
Target:
NAMPT
Application Notes:
MCE Product type: Reference compound
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