TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells[1].
Molecular Weight:
491.33
Purity:
99.92
CAS Number:
[2253744-56-6]
Formula:
C20H20Cl2N8O3
Target:
Others
Application Notes:
MCE Product type: Reference compound
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