Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 µM and an IC50 of 52.3 µM. Dantrolene is also a calcium channel protein inhibitor. Dantrolene inhibits the release of Ca2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties[1][2][3][4][5][6][7][8][9][10][11].
Molecular Weight:
314.26
Purity:
98.38
CAS Number:
[7261-97-4]
Formula:
C14H10N4O5
Target:
Apoptosis,Calcium Channel,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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