TXA497 is a potent local topical bactericide. TXA497 exerts its bactericidal effect by interfering with the polymerization kinetics of the bacterial cell division protein FtsZ, rather than inhibiting it. TXA497 shows strong activity against various Staphylococcus aureus strains, including MRSA and MSSA, with an MIC value ranging from 1.0 to 2.0 µg/mL. TXA497 skin deposition is concentration-dependent in its formulation, consistent with Ficks first law. TXA497 has limited systemic permeability through the lipid pathway of the stratum corneum and is easily absorbed through this route. TXA497 can be used for research on topical bactericidal agents[1].
Molecular Weight:
281.40
CAS Number:
[1404289-52-6]
Formula:
C18H23N3
Target:
Bacterial
Application Notes:
MCE Product type: Reference compound
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