VRT-18858 (RU-36384), the active metabolite of Pralnacasan (HY-19676), is a potent interleukin-1beta converting enzyme (ICE) inhibitor (Ki = 1.4 nM). VRT-18858 inhibits LPS (HY-D1056)-induced IL-1beta release (IC50 = 0.42 µM) and S. aureus Cowan-induced IL-1beta and IL-18 release (IC50=1.3 and 2.1 µM, respectively) in human peripheral blood mononuclear cells. VRT-18858 can be used for osteoarthritis research[1].
Molecular Weight:
495.48
CAS Number:
[192756-07-3]
Formula:
C24H25N5O7
Target:
Interleukin Related
Application Notes:
MCE Product type: Reference compound
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