CP-394531 is an efficient and highly selective non-steroidal glucocorticoid receptor (GR) antagonist, with a Ki value of 0.1 nM. CP-394531 has a weak binding to androgen receptor (AR) (Ki = 130 nM), and has almost no effect on progesterone receptor (PR) and estrogen receptors (ERalpha, ERbeta). CP-394531 completely blocks the half-maximal agonistic effect induced by Dexamethasone (HY-14648G), with a Kif of 4.1 nM. CP-394531 can be used to study various diseases such as diabetes, obesity, depression, neurodegenerative diseases, glaucoma and Cushings disease[1].
Molecular Weight:
366.88
CAS Number:
[305822-63-3]
Formula:
C23H23ClO2
Target:
Androgen Receptor,Glucocorticoid Receptor
Application Notes:
MCE Product type: Reference compound1
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