ML375 (VU0483253) is a potent, highly selective, brain-penetrant and orally active M5 mAChR negative allosteric modulator (NAM) with IC50s of 300 nM and 790 nM for human and rat M5, respectively. ML375 is inactive at human and rat M1-M4[1].
Molecular Weight:
424.83
Purity:
99.70
CAS Number:
[1488362-55-5]
Formula:
C23H15ClF2N2O2
Target:
mAChR
Application Notes:
MCE Product type: Reference compound
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