Sulfo galactosylceramide (N-Nervonoyl Sulfatide, C24:1 Sulfatide) is a glycolipid and the major sulfolipid species in mature myelin. Sulfo galactosylceramide interacts with C-type lectins and immunoglobulin-like receptors, with the highest affinity for LMIR5. Sulfo galactosylceramide induces MCP-1 production by basophils but not mast cells, and increases NFAT activation via LMIR5. Sulfo galactosylceramide alleviates symptoms and improves survival in a mouse model of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE), and reduces inflammatory lesions and the number of infiltrating mononuclear cells in the lumbar spinal cord of EAE mice.
Molecular Weight:
890.30
CAS Number:
[151057-28-2]
Formula:
C48H91NO11S
Target:
Nuclear Factor of activated T Cells (NFAT)
Application Notes:
MCE Product type: Reference compound1
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