Ginsenoside F2 is an orally active bioactive compound that participates in the regulation of metabolism and inflammation. Ginsenoside F2 promotes the phosphorylation of AMPK and ACC, binds to PPARgamma, inhibits the phosphorylation of MAPK, activates the PI3K/AKT/GSK-3beta pathway, reduces GLRX expression, and regulates lipid metabolism. Ginsenoside F2 reduces ROS production and MDA levels, restores SOD activity in cells, and alleviates oxidative stress. Ginsenoside F2 induces cell apoptosis (Apoptosis) and increases the number of cleaved caspase-3-positive cells. Ginsenoside F2 reduces body weight gain, adipose tissue weight and serum lipid levels in obese mice, and activates the hepatic AMPK signaling pathway and the expression of antioxidant enzymes. Ginsenoside F2 alleviates atopic dermatitis in mice by inhibiting inflammation and reshaping the gut microbiota[2]. Ginsenoside F2 is applicable to research related to insulin resistance, obesity, atopic dermatitis, liver cancer, glioblastoma and glioma[1][2][3][4].
Molecular Weight:
785.01
Purity:
99.95
CAS Number:
[62025-49-4]
Formula:
C42H72O13
Target:
Akt,AMPK,Apoptosis,Caspase,GSK-3,p38 MAPK,PI3K,PPAR,Reactive Oxygen Species (ROS),SOD
Application Notes:
MCE Product type: Natural Products
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