Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC50: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response[1].
Molecular Weight:
414.47
Purity:
99.90
CAS Number:
[2290527-07-8]
Formula:
C25H23FN4O
Target:
DNA/RNA Synthesis,RAD51
Application Notes:
MCE Product type: Reference compound
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