AMG-1694 is a potent glucokinase-glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1].
Molecular Weight:
533.63
Purity:
98.03
CAS Number:
[1361217-07-3]
Formula:
C23H30F3N3O4S2
Target:
Glucokinase
Application Notes:
MCE Product type: Reference compound
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