BAY-866, a sulfamide campound, is an allosteric MEK1 inhibitor with an IC50 of 14 nM. BAY-866 inhibits cell growth of A375 (BRAF) and HCT116 (K-Ras) with IC50s of 13 nM and 277 nM, respectively. BAY-866 inhibits tumor growth in K-Ras-mutated A549 xenograft model[1].
Molecular Weight:
596.29
CAS Number:
[1836185-18-2]
Formula:
C19H13F4IN4O4S
Target:
MEK
Application Notes:
Reference compound
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