JH-RE-06-d6 is deuterium labele JH-RE-06. JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 µM, Ki=0.42 µM), targets REV1 that interacts with the REV7 subunit of POLzeta. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLzeta. JH-RE-06 improves chemotherapy[1].
Molecular Weight:
474.75
Purity:
98.04
Formula:
C20H10D6Cl3N3O4
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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