CDK9-IN-7 (compound 21e) is a selective, highly potent, and orally active CDK9/cyclin T inhibitor (IC50=11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD=148 nM, CDK6/cyclinD=145 nM). CDK9-IN-7 shows antitumor activity without obvious toxicity. CDK9-IN-7 induces NSCLC cell apoptosis, arrests the cell cycle in the G2 phase, and suppresses the stemness properties of NSCLC[1].
Molecular Weight:
547.71
Purity:
98.05
CAS Number:
[2369981-71-3]
Formula:
C29H37N7O2S
Target:
Apoptosis,CDK
Application Notes:
MCE Product type: Reference compound1
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