SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 shifts NAMPT to NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD+. SBI-797812 increases intracellular nicotinamide mononucleotide (NMN) and elevates liver NAD+ in mice[1][2].
Molecular Weight:
402.47
Purity:
99.88
CAS Number:
[2237268-08-3]
Formula:
C19H22N4O4S
Target:
NAMPT
Application Notes:
MCE Product type: Reference compound
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