PRMT5 IN-1 hydrochloride (compound 9), a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 hydrochloride can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions[1].
Molecular Weight:
455.29
Purity:
99.51
Formula:
C19H20Cl2N4O5
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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